Description
This induced pluripotent stem cell line was reprogrammed by using non-integrating sendai viral vectors to reprogram peripheral blood mononuclear cells. The donor of AIBNi018-A is a male carrier of a heterozygous variant in the CYP2U1 gene and is a parent of the donor of AIBNi016-A who has been diagnosed with Hereditary Spastic Paraplegia 56. AIBNi018-A is described as having a normal karyotype. Expression of OCT4, SOX2, NANOG, TRA-1-60 and TRA-1-81 in undifferentiated cells, and directed differentiation to endoderm, mesoderm and ectoderm have been reported.
Tissue & Disease as reported
Genetic Information
Associated Publications
| Journal | Year | Article |
|---|---|---|
| Stem cell research | 2022 | Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations |
Line Custodianship
Cell Line Maintainer
Ernst Wolvetang
Affiliated Institutions
- Australian Institute for Bioengineering and Nanotechnology, Brisbane, Australia
Cell Line Producer
Australian Institute for Bioengineering and Nanotechnology
Affiliated Institutions
- Australian Institute for Bioengineering and Nanotechnology, Brisbane, Australia