MNZTASi006-A

Not yet reviewed by Australian Stem Cell Registry

2161-4, TOB-02161, MS_0005

Details

Tissue & Disease as reported

Disease as reported (Donor)
primary progressive multiple sclerosis

Genetic Information

No genetic information available for this cell line

Associated Publications

No available publications

Line Custodianship

Cell Line Maintainer

Menzies Institute for Medical Research

Affiliated Institutions
  • Menzies Institute for Medical Research, Hobart, Australia
View all cell lines from this group

Cell Line Producer

Menzies Institute for Medical Research

Affiliated Institutions
  • Menzies Institute for Medical Research, Hobart, Australia

Source

Donor Derived

Age: Unknown

Biological Sex: Female

Disease: EFO:0008520
Label: primary progressive multiple sclerosis
Definition: A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.| Primary progressive multiple sclerosis is the form of the multiple sclerosis in which clinical disability progression occurs continuously without remissions.

Derivation Details

Induced Pluripotent Cell Derivation Details

Source Cell Type: CL:0000842
Label: mononuclear leukocyte
Definition: A leukocyte with a single non-segmented nucleus in the mature form.

Source Cell Origin: UBERON:0003822
Label: forelimb stylopod
Definition: The part of the forelimb between pectoral region and the elbow, corresponding to the humerus.

Derivation Year:

Reprogramming Method

Vector Type: Not integrated

Vector: Sendai Virus

Ethics

Ethics Number: H0016915

Institution Human Research Ethics Council: University of Tasmania Human Research Ethics Committee

Approval Date: To be verified

Modifications

No genomic modifications available for this line.

Quality Assurance

Genomic Characterisation

Passage Number: Not available

Karyotype: female

Karyotype Method: Other

STR analysis Results:

Performed but not available.

Microbiology and Virology Screening

Disease Result
Mycoplasma Negative

Characterisation of Undifferentiated Cells

Marker Method
OCT4 RT-PCR
SOX2 RT-PCR

Scorecard Results

Undifferentiated Cells

No available data for this cell line.

Pluripotency

No available data for this cell line.

Pluripotency Characterisation

Endoderm

None

Assessed by: Unavailable

Markers: HNF4A

Mesoderm

None

Assessed by: Unavailable

Markers: GATA4

Ectoderm

None

Assessed by: Unavailable

Markers: Nestin

Growth Characteristics

Culture Medium and Growth Conditions

CO2 concentration: 5%

O2 concentration: 20%

Medium Items:

Passage Method: Enzymatically